2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W008151R
    Diphenyl Phosphate (Standard) 838-85-7 99.94%
    Diphenyl Phosphate inhibits growth and energy metabolism in zebrafish and mice in a sex-specific manner. Diphenyl Phosphate can inhibit the activity of SDH (respiratory complex II), reduce the expression of CPT1 and disrupts the integrity of the mitochondrial membrane. Diphenyl Phosphate may be used in research on metabolic diseases.
    Diphenyl Phosphate (Standard)
  • HY-W008385R
    H-HoArg-OH (Standard) 156-86-5 98.71%
    H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.
    H-HoArg-OH (Standard)
  • HY-W009208R
    Calcium L-Threonate (Standard) 70753-61-6 99.85%
    Calcium L-Threonate (Standard) is the analytical standard of Calcium L-Threonate (HY-W009208). This product is intended for research and analytical applications. Calcium L-Threonate, a calcium aldonate, is a calcium supplement. Calcium L-Threonate can be used for the study of osteoporosis.
    Calcium L-Threonate (Standard)
  • HY-W010104R
    L-Methionine sulfoxide (Standard) 3226-65-1 99.53%
    L-Methionine sulfoxide is an orally active oxidation product of Methionine (HY-N0326). L-Methionine sulfoxide can be partially converted into Methionine in the body and participate in the synthesis of glutathione in the liver. L-Methionine sulfoxide provides the body with sulfur activity and can participate in the synthesis of proteins and sulfur-containing compounds.
    L-Methionine sulfoxide (Standard)
  • HY-W010381R
    2-Methylsuccinic acid (Standard) 498-21-5 99.90%
    2-Methylsuccinic acid (Standard) is the analytical standard of 2-Methylsuccinic acid. This product is intended for research and analytical applications. 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy.
    2-Methylsuccinic acid (Standard)
  • HY-W011651R
    Carbutamide (Standard) 339-43-5
    Carbutamide (Standard) is the analytical standard of Carbutamide. This product is intended for research and analytical applications. Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity.
    Carbutamide (Standard)
  • HY-W012241S
    Dodecanedioic acid-d20 89613-32-1 99.0%
    Dodecanedioic acid-d20 is the deuterium labeled Dodecanedioic acid (HY-W012241). Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
    Dodecanedioic acid-d20
  • HY-W012946S
    2-Furoic acid-d3 40073-83-4 99.99%
    2-Furoic acid-d3 is the deuterium labeled 2-Furoic acid. 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats.
    2-Furoic acid-d3
  • HY-W014901S
    Bisphenol F-13C6 1410794-06-7 98.32%
    Bisphenol F-13C6 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260).
    Bisphenol F-13C6
  • HY-W015560R
    3,5-Dihydroxybenzoic acid (Standard) 99-10-5 99.96%
    3,5-Dihydroxybenzoic acid (Standard) is the analytical standard of 3,5-Dihydroxybenzoic acid. This product is intended for research and analytical applications. 3,5-Dihydroxybenzoic acid a potential biomarker for the consumption of many food products, including beer, nuts, peanut, and pulses. 3,5-Dihydroxybenzoic acid is the agonist for hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) that inhibits lipolysis in adipocytes. 3,5-Dihydroxybenzoic acid is the competitive inhibitor for tyrosine phenol-lyase (TPL), exhibits an affinity of Ki=25.7 μM. 3,5-Dihydroxybenzoic acid is orally active.
    3,5-Dihydroxybenzoic acid (Standard)
  • HY-W018004R
    L-Homocitrulline (Standard) 1190-49-4 99.96%
    L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI).
    L-Homocitrulline (Standard)
  • HY-W019151R
    Meconine (Standard) 569-31-3 98.60%
    Meconine (Standard) is the analytical standard of Meconine (HY-W019151). This product is intended for research and analytical applications. Meconine is an endogenous metabolite of Noscapine (HY-13716). Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use.
    Meconine (Standard)
  • HY-W040088R
    L-Alanyl-L-leucine (Standard) 3303-34-2 99.91%
    L-Alanyl-L-leucine is an endogenous metabolite. This product is used for research and analytical applications. L-Alanyl-L-leucine is a competitive inhibitor of small intestinal glycyl-L-leucine hydrolase with Ki values of 0.53 mM (phosphate buffer) or 0.22 mM (Tris buffer). L-Alanyl-L-leucine can be used for research on Hartnup disease and cystinuria.
    L-Alanyl-L-leucine (Standard)
  • HY-W040154R
    Cyclic N-Acetyl-D-mannosamine (Standard) 7772-94-3 99.95%
    Cyclic N-Acetyl-D-mannosamine (Cyclic ManNAc) is an endogenous metabolite.
    Cyclic N-Acetyl-D-mannosamine (Standard)
  • HY-W053787R
    1-Methylhistamine dihydrochloride (Standard) 6481-48-7 98.40%
    1-Methylhistamine dihydrochloride is a histamine metabolite.
    1-Methylhistamine dihydrochloride (Standard)
  • HY-W010255AS
    Phenylglyoxylic acid-d5sodium 2708283-39-8 99.79%
    Phenylglyoxylic acid-d5 (Benzoylformic acid-d5) sodium is the deuterium labeled Phenylglyoxylic acid sodium (HY-W010255A). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds.
    Phenylglyoxylic acid-d5sodium
  • HY-W013636S3
    2-Ketoglutaric acid-13C 108395-15-9
    2-Ketoglutaric acid-13C (Alpha-Ketoglutaric acid-13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM).
    2-Ketoglutaric acid-13C
  • HY-W017443S2
    L-Asparagine-13C4,15N2,d3 monohydrate 2483829-30-5 99.90%
    L-Asparagine-13C4,15N2,d3 monohydrate is the deuterium, 13C-, and 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-13C4,15N2,d3 monohydrate
  • HY-W014504R
    DL-Kynurenine (Standard) 343-65-7 98.52%
    DL-Kynurenine (Standard) is the analytical standard of DL-Kynurenine. This product is intended for research and analytical applications. DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity.
    DL-Kynurenine (Standard)
  • HY-12528
    DBPR108 1186426-66-3 99.93%
    DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9.
    DBPR108
Cat. No. Product Name / Synonyms Application Reactivity